Arsenal Host Saints, Reds Play Boro
The Third Round of the Capital One Cup gets under way on Tuesday with 10 matches, before a further six games the following day.
Round 2 of the Cup was the certainly the round of the scalp, with no less than six Football League sides upsetting Premier League opposition to progress.
This week's fixtures see sides involved in European tournaments enter the fray, with Chelsea, Liverpool, Arsenal, Tottenham, Everton and Hull City in action.
Manchester City also return to the competition as holders following their 3-1 win over Sunderland at Wembley back in March, taking on Sheffield Wednesday at the Etihad Stadium in Round 3.
There are two all-Championship fixtures on Tuesday, with Cardiff City hosting Bournemouth and Reading making the trip north to Derby County.
Five Sky Bet League 1 sides enjoyed Second Round victories, with MK Dons the pick of the bunch having recorded one of the most memorable results in the history of the League Cup, beating Manchester United 4-0 at Stadiummk.
Shrewsbury and Burton Albion are the only remaining Sky Bet League 2 clubs in the competition, and host higher-league opposition once more in Norwich City and Brighton & Hove Albion respectively.
Middlesbrough's visit to eight-time winners Liverpool will be shown live on Sky Sports on Tuesday, while Tottenham Hotspur and Nottingham Forest will meet in front of the cameras on Wednesday.
Another notable fixture sees an all-Premier League clash between Arsenal and Southampton. The Gunners will be looking to extend their strong record against their visitors in the competition. Arsene Wenger's men have never lost to the Saints in the League Cup, winning four and drawing two of their six meetings.
Last season's runners-up Sunderland face Stoke City at the Stadium of Light, and have also never recorded a League Cup win over Tuesday's opposition in their history, losing both of their two fixtures against them.
Arsenal v Southampton
Shrewsbury Town v Norwich City
Sunderland v Stoke City
Swansea City v Everton
Derby County v Reading
Cardiff City v Bournemouth
Liverpool v Middlesbrough
Leyton Orient v Sheffield United
MK Dons v Bradford City
Fulham v Doncaster Rovers
Burton Albion v Brighton and Hove Albion
Tottenham Hotspur v Nottingham Forest
Crystal Palace v Newcastle United
Manchester City v Sheffield Wednesday
Chelsea v Bolton Wanderers
West Bromwich Albion v Hull City