Malaria Vaccine Offers Hope In Fight Against The Killer Disease

How A Pilot Vaccine Initiative Is Working In Malawi.

By Veronica Mukhuna
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Clara Magalasi, who lives in a rural village near Lilongwe, the capital city of Malawi, woke up to a grey morning with a dull sky that was threatening rain.

For Ms. Magalasi, the weather did not stop her from walking the 4 kilometres to Chileka Health Centre. Her daughter Grace Butawo, who just turned 22 months, was due for her fourth and final dose of the RTS,S malaria vaccine. She is fully aware of the vaccine benefits.

“I understand that if my child gets all four doses, the vaccine will give her the most protection against malaria and severe malaria. Ever since Grace was born, she has never suffered from malaria, unlike my other children who experienced a lot of malaria episodes when they were her age,” says Ms. Magalasi.

When added to currently recommended malaria control tools, the RTS,S malaria vaccine can reduce episodes of malaria in children by 40 per cent and reduce life-threatening severe malaria by around 30 per cent.

Malaria vaccine pilot progress: two years on
Currently, Grace is one of the estimated 220,000 children in Malawi who have received at least one dose of the RTS,S malaria vaccine through routine immunization as part of a landmark pilot implementation in sub-Saharan Africa – led by the Ministries of Health in Malawi, Ghana, and Kenya, coordinated by the United Nations, through the World Health Organisation (WHO), and supported by in-country and regional and global health partners.

In Malawi, malaria is among the three most deadly diseases among children under five years old, alongside pneumonia and diarrhoea. WHO and UNICEF have been working together with health authorities to combat the disease, as it is preventable and easily treatable if caught early.

And when the moment came two years ago to introduce the malaria vaccine into childhood immunization programmes in the world, Malawi became the first country to get on board, followed by Ghana and then Kenya. The vaccine was introduced in a phased approach that targeted 11 districts in Malawi.

Globally, more than half of childhood deaths occur in Africa, and malaria is a major cause of these. In January 2016, the WHO recommended pilot implementation of the RTS,S malaria vaccine in children to use alongside other malaria control interventions in settings of moderate-to-high parasite transmission. The malaria vaccine is the first and, to date, the only vaccine that can significantly reduce malaria in children.

The power of immunization to increase health equity

“To reduce childhood deaths, we can look to the potential of interventions like the malaria vaccine to deliver added malaria prevention on the successful child vaccination or EPI platform that reaches about 80 per cent of children in the country. The vaccine provides considerable added protection against malaria to children.

Clara Magalasi and her child Grace Butawo at her home in Lilongwe Rural. The child has received malaria vaccine and now has more protection against the disease. © Photo: WHO Malawi/ Hudson Kubwalo.

It is an additional tool alongside insecticide-treated nets (or bed nets) and it is also an opportunity to reach children not yet using bed nets or other malaria prevention interventions – the malaria vaccine could increase equity in access to life-saving malaria interventions,” said Dr. Nonhlanhla Dlamini the WHO Representative in Malawi.

Malawi’s Ministry of Health has put in place malaria control measures such as insecticide-treated nets (ITNs) and indoor residual spraying with insecticides (IRS) supported by UNICEF and WHO. However, there are still households in hard-to-reach areas that do not yet benefit from such interventions.

As Seliya Lawrence, also from rural Lilongwe, says, her house never got insecticides but her 10-month-old baby has so far received 3 doses of malaria vaccine.

“I know about IRS but that programme did not come in our area. I am grateful that my child is getting the malaria vaccine which can protect her from severe malaria,” said Ms. Lawrence.

Other potential benefits: reduced hospital admissions, more preventive health care visits

Hospital visits and admissions due to malaria put a financial burden on the vulnerable. In Malawi, almost 60 per cent of childhood outpatient health facility visits are due to malaria. Data from Chileka Health Centre in Lilongwe indicates a decrease in hospital admissions for malaria illness among children under age five years since the vaccine was introduced. Health workers say this drop may be due to the malaria vaccine.

“Since the malaria vaccine was introduced, it may have managed to keep many children out of the hospital,” says Madalitso Chadewa, a senior Health Surveillance Assistant at Chileka Health Centre.

Ms. Chadewa says the pilot has also improved the routine immunization uptake. Before the pilot, most mothers would quit under-five clinic visits when their children get their last jab of measles at 15 months. But the malaria vaccine has extended the immunization period to 22 months of age.

“When children come at 22 months, aside from giving them the RTS,S fourth dose, we also do growth monitoring and general health checks. These health checks are essential because they help to detect preventable health threats in the under-five children,” she added.

Malaria vaccine pilot in the context of COVID-19
The UN has been supporting the Malawi’s Ministry of Health to ensure the continuity of essential immunization and malaria services during the COVID-19 pandemic, including malaria vaccination in pilot districts. The malaria vaccine pilot has continued without major disruptions.

“We understand how COVID-19 has put pressure on our health system. It is important for us to ensure that child vaccination services, including the malaria vaccine programme, continue during this time because immunizations reduce child illnesses, save lives, and help relieve the strain on the health system,” says Dr. Randy Mungwira, the WHO technical officer for the malaria vaccine pilot programme in Malawi.

Next steps for the malaria vaccine pilot
Data and experience from the malaria vaccine in pilot implementation will inform how best to reach children with the four-dose vaccine regimen, the vaccine’s impact on severe malaria and on lives saved, and the vaccine’s safety in routine use. So far, accrued safety data are very reassuring.

The pilot is progressing well, community acceptance of the vaccine is strong, and the programme is now on track for a review of RTS,S data and a potential WHO vaccine recommendation for wider use in sub-Saharan Africa as early as October 2021. If the vaccine is recommended for broader use, it could be a potent new addition to currently recommended tools to fight malaria, delivered through the childhood immunization platform.

The Malaria Vaccine Implementation Programme in the African region derives from the UN’s partnership with Gavi, the Vaccine Alliance, the Global Fund to Fight AIDS, Tuberculosis and Malaria, and Unitaid.

For more information, go to the malaria vaccine implementation programme website.

Ms. Mukhuna works for WHO in Malawi
For more information on COVID-19, visit

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